[A new anagesic drug: pregabalin; and the first intoxications].

نویسندگان

  • Enver Belli
  • Kerem Erkalp
  • Zehra Yangın
  • Sibel Fadıllıoğlu
  • Ayşin Alagöl
چکیده

Pregabalin is an antiepileptic, analgesic and anxiolytic drug that GABA analogue with similar structure and actions to gabapentin. There are very few reports about pregabalin intoxication in the literature. A 24-year-old male presented following ingestion of 3 g of pregabalin in this report. He was managed with General Supportive Care and Symptomatic Approach (GSCSA) such as discontinuation of the drug, hydration with IV fluids, oxygenation, gastric lavage and activated charcoal administration and enhanced elimination techniques. But, it is to be noted that either the kidneys of the patients are in good functioning state or there is a hemodialysis facility in the immediate vicinity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثرات پیش داروی پره گابالین در مقایسه با دارونما بر درد حاد پس از هیسترکتومی شکمی

Background and aims: Although pregabalin is primarily an anticonvulsive drug and is alsoeffective on chronic neuropathic pain, there are limited data regarding its effect on acute pain. Inthis study we assessed the analgesic effect of pregabalin on acute post operative pain used aspreemptive analgesia in comparison to placebo and compared pain intensity and opiumrequirements among placebo and p...

متن کامل

Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test

The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

متن کامل

Injury to skeletal muscle of mice following acute and sub-acute pregabalin exposure

Objective(s): Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. Materials and Methods: To evaluate the effect of PGB on skeletal...

متن کامل

گزارش یک مورد نادر بی اختیاری ادراری به دنبال مصرف تک دوز پره گابالین

Pregabalin is used as a new drug in relieving neuropathic pain but it could have some side effects such as dizziness, drowsiness and peripheral edema. Other side effects are rarely reported. We report a patient who developed urinary incontinence following a single dose of Pregabalin. A 72 year old woman was diagnosed with depression and received treatment from two years ago but complained of sc...

متن کامل

Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test

The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology

دوره 25 4  شماره 

صفحات  -

تاریخ انتشار 2013